Tocotrienol and Pancreatic CancerRecep DEMİR
Pancreatic cancer is one of the leading causes of cancer-related death due to its aggressive behaviour and resistance to current therapies. The 5-year survival rate of pancreatic cancer is a dismal and to improve current therapies is a health research priority.
Tocotrienols are naturally occurring vitamin E compounds found in barley, oats, rice bran and palm. These molecules display a diversity of biological and physiology properties including potent antioxidant effects.
One pre-clinical studies identified gamma tocotrienol as the most bioactive of the 4 natural compounds (alfa, beta, gamma and delta) against pancreatic cancer cells in vitro and in vivo. It has also been observed that delta tocotrienol is adequately concentrated in mice pancreas after oral ingestion.
Thus, future studies would be conducted in patients with pancreatic cancer aimed to investigate both the safety of delta tocotrienol and its effective dosage to treat pancreatic cancer.